Clinical Trials

Upcoming Clinical Trials

 

Many clinical trials are on the horizon! Stay tuned!


Current Clinical Trials

 Magnesium Clinical Trial

The two-year study of oral magnesium supplementation as an investigational treatment for pseudoxanthoma elasticum (PXE) concluded in April 2015 at Mt. Sinai in New York. The process now is to unblind the data to reveal who took magnesium and who took the placebo in the first year. Everyone took the magnesium supplement in the second year. Researchers will compile, clean and analyze the data, discuss and form conclusions, and write and submit a journal article. If the paper is accepted on the first submission, it will be published three to six months after submission. If it is rejected, then the path to publication will be much longer. Results of the magnesium supplement clinical trial cannot be revealed until the paper is published. 

Click here for more information on the clinical trial of magnesium supplements in the treatment of PXE.

 Let Your Voice Be Heard!

What is it like to participate in a clinical trial?. We'll let the participants tell us! Here are the stories of PXEers who are part of the two-year magnesium supplement clinical trial at Mt. Sinai in New York, which crossed the one-year milestone several months ago.

A Tale of the Trial - Pseudoxanthoma Elasticum, Magnesium and Me by Jessie Gower
Scientific - and Magical! by JoAnn Defrancesco
A Rewarding Experience by Chris Rumer
Adventure of Hope by Mary Ann Thaman
 


March 2014


To all PXE Magnesium Supplement Clinical Trial participants – Let your voice be heard!
Tell us about your experience in the clinical trial

By now, the participants in the PXE Magnesium Supplement Clinical Trial have either crossed over or are approaching their one-year anniversary in the trial – congratulations participants!! This clinical trial is a historic event, and PXE International is eager to learn about your experience, as is the entire PXE community! Why did you volunteer? What were your expectations? What has been the hardest or easiest part?

We have an opportunity for you – let your voice be heard by writing about your experience in the trial thus far for publication in a future issue of the PXE International eNewsletter and on pxe.org. It can be short or long, creative or straight-forward. How about a photo essay! Whatever it is, it is your story and we want to hear it!

Please email Terry Mac Dermaid or call (202-362-9599, extension 222) to let her know you are interested.

 


May 2013


Press Release

Washington, DC, May 30, 2013 – A clinical trial to test the effectiveness of magnesium supplementation as a treatment for pseudoxanthoma elasticum (PXE) is underway at the Mount Sinai School of Medicine in New York City, NY. This trial is the first of its kind in PXE history. PXE International is a partner in the trial’s recruitment and research.    Read the Press Release
 


Photo Essay

"Making History of PXE: Elizabeth Terry's Experience of the PXE Clinical Trial"
What's it like to participate in a clinical trial?    Read Elizabeth's story

 


Interviews with the Clinical Trial Team

PXE International spoke with some of the members of the Mt. Sinai PXE Clinical Trial Team to see what it was like on the other side of the clinical trial experience. Read the interviews.

Wayne Fuchs, MD, Clinical Professor of Ophthalmology at Mt. Sinai Hospital in New York
Shelbi Jim On, MD, Dermatopharmacology Fellow at Mt. Sinai School of Medicine Department of Dermatology
Giselle Singer, Director of Clinical Trials, Mt. Sinai School of Medicine Department of Dermatology
 


Frequently Asked Questions

What are the criteria for participating in this trial?
What are the side effects of a magnesium supplement?
What will happen to participants during this trial?

Get answers to frequently asked questions about the PXE clinical trial.
 


Helpful Links

Here are links to additional Information on:
This study NCT01525875
Magnesium oxide
Magnesium
Dietary supplements

 


Mark Lebwohl

January 2013


Clinical Trial Progress Report

January 10, 2013 – This is a very exciting time in the PXE community as there is finally a clinical trial to test a treatment for PXE! Dr. Mark Lebwohl and his research team at Mt. Sinai School of Medicine Dermatology Department will conduct the trial. A total of 44 volunteers will participate in this two-year study of oral magnesium supplementation as an investigational treatment for PXE. The trial began January 2013 and continues until January 2015.