Michael A. Dean, PhD

 

 


 

Chief, Human Genetics Section
Laboratory of Experimental Immunology

National Cancer Institute (NCI), Frederick, MD


Dr. Dean obtained his Ph.D. from the Biochemistry Department at the Boston University School of Medicine. He performed his postdoctoral studies at the National Cancer Institute on the MET oncogene and cystic fibrosis gene. He is a member of the American Society of Human Genetics, American Association of Cancer Research, Centre Etude du Polymorphisme Humaine (CEPH), the Human Genome Organization (HUGO), and an adjunct faculty member at Hood College. He has worked for many years on ABC transporters.

 


Areas of Interest


Genetics of PXEPXE Animal ModelsPXE and the Metabolism

 


Publications


Silverton L, Dean M, Moitra K. Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease. Drug Metabol Drug Interact. 2011;26(4):169-79. Review. PMID: 22098604

Moitra K, Silverton L, Limpert K, Im K, Dean M. Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps. Drug Metabol Drug Interact. 2011;26(3):105-11. Review. PMID: 21942345

Moitra K, Lou H and Dean M. Multidrug efflux pumps and cancer stem cells: Insights into multidrug resistance and therapeutic development. Clin Pharmacol Ther. 2011 Apr;89(4):491-502. PMID: 21368752

Fukuda Y, Aguilar-Bryan L,Vaxillaire M, Dechaume A, Wang Y, Dean M, Moitra K, Bryan J and Schuez JD. Conserved intramolecular disulphide bond is critical to the trafficking and fate of ATP binding cassette (ABC) transporters ABCB6 and sulphonyl urea receptor. J Biol Chem. 2011 Mar 11;286(10):8481-92. PMID: 21199866

Moitra K, Scally M, McGee K, Lancaster G, Gold B and Dean M. Molecular evolutionary analysis of ABCB5: The ancestral gene is a full transporter with potentially deleterious single nucleotide polymorphisms. PLoS One. 2011 Jan 27;6(1):e16318. Free article. PMID: 21298007

Moitra K, Dean M. Evolution of ABC transporters by gene duplication and their role in human disease. Biol Chem. 2011 Jan;392(1-2):29-37. Review. PMID: 21194360

Li Q, Sadowski S, Frank M, Chai C, Varadi A, Ho S, Lou H, Dean M, Thisse C, Thisse B, Uitto J. The abcc6a gene expression is required for normal zebrafish development. J Invest Dermatol. 2010 Nov;130(11):2561-8.Free article in PubMed. PMID: 20596085

Dean M. ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol. 2009 Mar;14(1):3-9. Review. PMID: 19224345

Allikmets R, Dean M. Bringing age-related macular degeneration into focus. Nat Genet. 2008 Jul;40(7):820-1. PMID: 18583975

Henrich CJ, Robey RW, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, Dean M, McMahon JB. New inhibitors of ABCG2 identified by high-throughput screening. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3271-8. Free article in PubMed. PMID: 18089721