ABCC6

October 11, 2008
5th Annual North American ABC Meeting
A key session at the ABC meeting, titled "Pseudoxanthoma elasticum, ABCC6, and Vitamin K?", generated vigorous discussion, and PXE International is pursuing new leads. 

November 3, 2009
Do Other Genes Influence the Severity of PXE?

October 7, 2010
The ABCC6 (MRP6) Gene and Gene Patenting
PXE International, a non-profit research foundation, is the owner of the intellectual property rights in the form of multiple worldwide patents issued for the diagnostic and therapeutic use of the gene associated with PXE, ABCC6. What does being the patent holder mean?

October 28, 2011
Rescue of ABCC6 Disease-Causing Mutations in Mouse Liver
In a very complex experiment, a team of PXE researchers led by Dr. Váradi and Dr. Le Saux were able to rescue some function in an ABCC6 gene with disease-causing mutations in a live mouse liver. This news is very exciting and may have some application to a future therapy for pseudoxanthoma elasticum in humans.

This article first appeared in the October 2010 eNewsletter.
Updated 09/15/2020

History of the ABCC6 gene

Since its founding in 1995, PXE International has been a catalyst in just about all research on pseudoxanthoma elasticum (PXE). When the Terry’s children were diagnosed in 1994, it was immediately clear to them that there was a need to bring the community together around one goal - finding a way to mitigate the suffering endured by people affected by PXE.