Lionel Bercovitch, MD

Scientific and Medical Chair, PXE International
Professor of Dermatology, Brown Medical School, Providence, RI


Dr. Lionel Bercovitch, the founding medical director of PXE International, is uniquely qualified as an advocate, clinician, and researcher for PXE. He became intensely involved in PXE following his diagnosis of Elizabeth and Ian Terry with the disorder in 1994. Since then, he has authored many papers on PXE, examined hundreds of people affected by PXE, some of whom have come from all over the US and as far away as South America and Australia for second opinions,  and given much of his spare time to research on the condition. He does comprehensive clinical evaluations of PXEers, has been actively involved in many clinical research projects, and is a clinical resource for healthcare professionals and laypersons alike.

Dr. Bercovitch is Professor of Dermatology at Warren Alpert Medical School of Brown University, Providence, RI, and serves as Director of Pediatric Dermatology at Hasbro Children's Hospital, also in Providence. He is Co-Editor-in-Chief of Pediatric Dermatology. He is also heavily involved in bioethics education for dermatology residents.

Dr. Bercovitch is a graduate of the University of Manitoba Medical School in Canada, is board certified (US) in Dermatology, Pediatric Dermatology and Internal Medicine, and is a Fellow of the Royal College of Surgeons of Canada in Ophthalmology.




Presentations at the 2012 Biennial Conference and Prior 

  • Plenary Address
  • Women's Issues in PXE
  • General Q & A


Areas of Interest

Genetics of PXEPXE and the MetabolismClinical ManifestationsEpidemiology of PXEClinical Trials



Uitto J, Váradi A, Bercovitch L, Terry PF, Terry SF. Pseudoxanthoma elasticum: Progress in research toward treatment: Summary of the 2012 PXE International research meeting. J Invest Dermatol. 2013 Jun;133(6):1444-9.Lay summaryFree article at Journal Website. PMID: 23673496


Wang AR, Fonder MA, Telang GH, Bercovitch L, Robinson-Bostom L. Late-onset focal dermal elastosis: An uncommon mimicker of pseudoxanthoma elasticum. J Cutan Pathol. 2012 Oct;39(10):957-61. PMID: 22882354


Uitto J, Bercovitch L, Terry SF, Terry PF. Pseudoxanthoma elasticum: Progress in diagnostics and research towards treatment: Summary of the 2010 PXE International Research Meeting. Am J Med Genet A. 2011 Jul;155A(7):1517-26. Lay summaryFree article in PubMed. PMID: 21671388


Bercovitch L, Martin L, Chassaing N, Heffron TW, Bessis D, Vanakker V, Terry SF. Acquired pseudoxanthoma elasticum presenting after liver transplantation. J Am Acad Dermatol. 2011 May;64(5):873-8. Lay summaryFree article in PubMed. PMID: 21397982


Ramsay M, Greenberg T, Lombard Z, Labrum R, Lubbe S, Aron S, Marais AS, Terry S, Bercovitch L, Viljoen D. Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals. J Dermatol Sci. 2009 Jun;(54)3:198-204. PMID: 19339160


Garcia-Fernandez MI, Gheduzzi D, Boraldi F, Paolinelli CD, Sanchez P, Valdivielso P, Morilla MJ, Quaglino D, Guerra D, Casolari S, Bercovitch L, Pasquali-Ronchetti I. Parameters of oxidative stress are present in the circulation of PXE patients. Biochim Biophys Acta. 2008 Jul-Aug;1782(7-8):474-81. PMID: 18513494


Vanakker OM, Leroy BP, Coucke P, Bercovitch LG, Uitto J, Viljoen D, Terry SF, Van Acker P, Matthys D, Loeys B, De Paepe A. Novel clinico-molecular insights in pseudoxanthoma elasticum provide an efficient molecular screening method and a comprehensive diagnostic flowchart. Hum Mutat. 2008 Jan;29(1):205. Free article at Journal Website. PMID: 18157818


Pfendner EG, Vanakker OM, Terry SF, Vourthis S, McAndrew PE, McClain MR, Fratta S, Marais AS, Hariri S, Coucke PJ, Ramsay M, Viljoen D, Terry PF, De Paepe A, Uitto J, Bercovitch LG. Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet. 2007 Oct;44(10):621-8. Free article in PubMedPatient Summary. PMID: 17617515


Shi Y, Terry SF, Terry PF, Bercovitch LG, Gerard GF. Development of a rapid, reliable genetic test for pseudoxanthoma elasticum. J Mol Diagn. 2007 Feb;9(1):105-12. Free article in PubMed. PMID: 17251343


Terry SF, Terry PF, Rauen KA, Uitto J, Bercovitch LG. Advocacy groups as research organizations: the PXE International example. Nat Rev Genet. 2007 Feb;8(2):157-64.  Free article. PMID: 17230202


Bercovitch RS, Januario JA, Terry SF, Boekelheide K, Podis AD, Dupuy DE, Bercovitch LG. Testicular microlithiasis in association with pseudoxanthoma elasticum. Radiology. 2005 Nov;237(2):550-4. Free article at journal websitePatient SummaryPoster: Testicular Microlithiasis in PXE. PMID: 16244264


Bercovitch L, Leroux T, Terry S, Weinstock MA. Pregnancy and obstetrical outcomes in pseudoxanthoma elasticum. Br J Dermatol. 2004 Nov;151(5):1011-8. Journal articlePatient Summary. PMID: 15541079


Bercovitch L, Terry P. Pseudoxanthoma elasticum (2004). J Am Acad Dermatol. 2004 Jul;51(1 Suppl):S13-4. Review. PMID: 15243491


Gheduzzi D, Sammarco R, Quaglino D, Bercovitch L, Terry S, Taylor W, Ronchetti IP. Extracutaneous ultrastructural alterations in pseudoxanthoma elasticum. Ultrastruct Pathol. 2003 Nov-Dec;27(6):375-84. PMID: 14660276


Bercovitch L, Robinson-Bostom L, Terry SF, Pasquali-Ronchetti I, Harrist T. Re: yellowish papules on flexural areas in a child. Pediatr Dermatol. 2003 Nov-Dec;20(6):543-5; author reply 545. PMID: 14651582


Lebwohl M, Lebwohl E, Bercovitch L. Prominent mental (chin) crease: a new sign of pseudoxanthoma elasticum.J Am Acad Dermatol. 2003 Apr;48(4):620-2. Patient Summary. PMID: 12664032


Bercovitch L, Schepps B, Koelliker S, Magro C, Terry S, Lebwohl M. Mammographic findings in pseudoxanthoma elasticum. J Am Acad Dermatol. 2003 Mar;48(3):359-66. Patient Summary. PMID: 12637915


Le Saux O, Beck K, Sachsinger C, Treiber C, Göring HH, Curry K, Johnson EW, Bercovitch L, Marais AS, Terry SF, Viljoen DL, Boyd CD. Evidence for a founder effect for pseudoxanthoma elasticum in the Afrikaner population of South Africa. Hum Genet. 2002 Oct;111(4-5):331-8. PMID: 12384774


Le Saux O, Beck K, Sachsinger C, Silvestri C, Treiber C, Göring HH, Johnson EW, De Paepe A, Pope FM, Pasquali-Ronchetti I, Bercovitch L, Marais AS, Viljoen DL, Terry SF, Boyd CD. A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum. Am J Hum Genet. 2001 Oct;69(4):749-64. Free article in PubMed. PMID: 11536079


Gheduzzi D, Taparelli F, Quaglino D Jr, Di Rico C, Bercovitch L, Terry S, Singer DB, Pasquali-Ronchetti I. The placenta in pseudoxanthoma elasticum: clinical, structural and immunochemical study. Placenta. 2001 Jul;22(6):580-90. Download the PDF of this article. PMID: 11440547


Terry SF, Bercovitch L, Boyd C (June 2001) Pseudoxanthoma elasticum (PXE). In: GeneClinics: Clinical Genetic Information Resource [database online]. Copyright, University of Washington, Seattle. Available at PMID: 20301292


Sherer DW, Bercovitch L, Lebwohl M. Pseudoxanthoma elasticum: significance of limited phenotypic expression in parents of affected offspring. J Am Acad Dermatol. 2001 Mar;44(3):534-7. PMID: 11209132


Le Saux O, Urban Z, Tschuch C, Csiszar K, Bacchelli B, Quaglino D, Pasquali-Ronchetti I, Pope FM, Richards A, Terry S, Bercovitch L, de Paepe A, Boyd CD. Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet. 2000 Jun;25(2):223-7. PMID: 10835642


Le Saux O, Urban Z, Göring HH, Csiszar K, Pope FM, Richards A, Pasquali-Ronchetti I, Terry S, Bercovitch L, Lebwohl MG, Breuning M, van den Berg P, Kornet L, Doggett N, Ott J, de Jong PT, Bergen AA, Boyd CD. Pseudoxanthoma elasticum maps to an 820-kb region of the p13.1 region of chromosome 16. Genomics. 1999 Nov 15;62(1):1-10. PMID: 10585762

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