1997: International Centennial Meeting
A two-day symposium entitled International Centennial Meeting on Pseudoxanthoma Elasticum was held in Bethesda, Maryland on November 6-7, 1997. This meeting was organized on the premise that significant progress had been made in pseudoxanthoma elasticum (PXE) research. The purpose of the meeting was to bring together investigators for an open exchange regarding recent advances. Topics included genetics, cell biology, elastic fibers, and clinical aspects of PXE. Results of this meeting guided further research in the field. The meeting was supported by the United States Public Health Service through the National Institutes of Health.
Click here: Summary article in Journal of Investigative Dermatology Uitto J, Boyd CD, Lebwohl MG, Moshell AN, Rosenbloom J, Terry S. International Centennial Meeting on Pseudoxanthoma Elasticum: progress in PXE research. J Invest Dermatol. 1998 May;110(5):840-2. PMID: 9579557 {PDF}
Presentations
Below you will find brief summaries of the presentations from this meeting.
Mapping of Both Autosomal Recessive and Dominant Variants of Pseudoxanthoma Elasticum to Chromosome 16p13.1
Berthold Struk, M.D., Brigham and Women's Hospital
Pseudoxanthoma Elasticum: A Sib Pair and Haplotype Analysis at 16p Reveals a Largely Dominant Disorder with Variable Penetrance in Unrelated Families from the United Kingdom and North America
Olivier Le Saux, Ph.D., The Pacific Biomedical Researcher Center, University of Hawaii
Localizing a Gene for Pseudoxanthoma Elasticum to Chromosome 16p13.1
Arthur Bergen, M.D., Netherlands Institute for Scientific Information Services
Physical Map of the PXE Region of Chromosome 16p13.12-13.11
Norman A. Doggett, Ph.D., Los Alamos National Laboratory
Genetic Heterogeneity of PXE
FM Pope, M.D., University Hospital of Wales
Pseudoxanthoma Elasticum in South Africa
Denis Viljoen, M.D., University of Cape Town Medical School
Phenotypic and Genetic Characteristics of PXE in Belgium and South Africa
Anne De Paepe, M.D., Ph.D., Belgium Center for Medical Genetics
Components of the Elastic Fiber: Multiple Proteins with Multiple Functions Robert P. Mecham, Ph.D., Washington University
Microfibrillar Proteins: The Long and the Short of It
Joel Rosenbloom, M.D., Ph.D., University of Pennsylvania
Regulation of Elastin Gene Expression
Jouni Uitto, M.D., Ph.D., Jefferson Medical College
Fibrillins and PXE
Allen Sapadin, M.D., Mount Sinai School of Medicine
The Pathobiology of Elastic Fibers
Charles Boyd, Ph.D., The Pacific Biomedical Research Center, University of Hawaii
Matrix Gla and Elastic Tissue
Gerard Karsenty, M.D., Ph.D., University of Texas
Italian Effort to Study PXE: From the Identification of Patients and Families to the Pathogenesis of the Disease
Ivonne Pasquali Ronchetti, Ph.D., University of Modena
Pathogenesis of PXE
Kenneth Neldner, M.D., Texas Tech University
Cutaneous Findings of PXE
Mark Lebwohl, M.D., Mt. Sinai School of Medicine
Mammographic Findings in Pseudoxanthoma Elasticum
Lionel Bercovitch, M.D., Brown University
Ocular Manifestations of Pseudoxanthoma Elasticum
Wayne Fuchs, M.D., Mt. Sinai School of Medicine
Animal Models and Pseudoxanthoma Elasticum
Richard Smith, M.D., The Jackson Laboratory
The Men, Women and Children of PXE
Richard Smith, M.D., The Jackson Laboratory